Pharmacodynamic analysis of time-variant cellular disposition: reticulocyte disposition changes in phlebotomized sheep
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چکیده
منابع مشابه
A pharmacodynamic analysis of erythropoietin-stimulated reticulocyte response in phlebotomized sheep.
The pharmacodynamics (PD) of the reticulocyte response resulting from phlebotomy-induced erythropoietin (EPO) was investigated in adult sheep. The anemia caused by the controlled phlebotomy (Hb < 4 g/dl, t = 0) resulted in a rapid increase in EPO with peak concentrations from 200 to 1400 mU/ml at 0.5 to 3 days generating a delayed reticulocyte response with peak levels from 9.3 to 14.1% at 2.5 ...
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Preparation of this manuscript was supported in part by grants from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR/AI44724, AR47298), the National Institute of Child Health and Human Development/National Center for Medical Rehabilitation Research (HD33989), and the Fetzer Institute. Portions of this paper were summarized at the second meeting of the Initiative on ...
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ژورنال
عنوان ژورنال: Journal of Pharmacokinetics and Pharmacodynamics
سال: 2007
ISSN: 1567-567X,1573-8744
DOI: 10.1007/s10928-007-9056-2